Misconceived bioethics?: The misconception of the "therapeutic misconception".

Clarifying the ethics of clinical research: a path toward avoiding the therapeutic misconception.

Clinical Trials and Medical Care: Defining the Therapeutic Misconception

What Is Therapeutic Misconception? For over three decades, bioethics scholarship and research ethics guidelines have identified concerns about the boundaries between research and standard clinical care [1,2]. Ethicists have argued that informed consent to participate in research should include clarification of the differences between these two activities [3–10]. In 1982, Appelbaum and colleague...

Beyond informed consent: the therapeutic misconception and trust.

The therapeutic misconception has been seen as presenting an ethical problem because failure to distinguish the aims of research participation from those receiving ordinary treatment may seriously undermine the informed consent of research subjects. Hence, most theoretical and empirical work on the problems of the therapeutic misconception has been directed to evaluate whether, and to what degr...

The therapeutic misconception at 25: treatment, research, and confusion.

"Therapeutic misconception" has been misconstrued, and some of the newer, mistaken interpretations are troublesome. They exaggerate the distinction between research and treatment revealing problems in the foundations of research ethics and possibly weakening informed consent.

Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials

BACKGROUND Participants in clinical trials frequently fail to appreciate key differences between research and clinical care. This phenomenon, known as therapeutic misconception, undermines informed consent to clinical research, but to date there have been no effective interventions to reduce it and concerns have been expressed that to do so might impede recruitment. We determined whether a scie...